Total Synthesis of Uniflorine A, Casuarine, Australine, 3-epi-Australine, and 3,7-Di-epi-australine from a Common Precursor

Ritthiwigrom, Thunwadee; Willis, Anthony C.; Pyne, Stephen G.

doi:10.1021/jo902355p.s003

jo902355p_si_003.pdf (12.95 MB)

Total Synthesis of Uniflorine A, Casuarine, Australine, 3-epi-Australine, and 3,7-Di-epi-australine from a Common Precursor

journal contribution

posted on 2010-02-05, 00:00 authored by Thunwadee Ritthiwigrom, Anthony C. Willis, Stephen G. Pyne

A flexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described.