Total Synthesis of (±)-Cephalosol

Xie, Yuanzhen; Wang, Ning; Cheng, Bin; Zhai, Hongbin

doi:10.1021/ol202923u.s001

ol202923u_si_001.pdf (2.49 MB)

Total Synthesis of (±)-Cephalosol

journal contribution

posted on 2016-02-22, 10:02 authored by Yuanzhen Xie, Ning Wang, Bin Cheng, Hongbin Zhai

A concise and efficient total synthesis of (±)-cephalosol has been completed (5 steps from known ester 5, 39% overall yield), featuring a Cu(II)-promoted haloisocoumarin formation and sequential Suzuki cross-coupling/intramolecular oxo-Michael addition.