ap9b01051_si_001.pdf (454.48 kB)
Temperature-Responsive Multilayer Films of Micelle-Based Composites for Controlled Release of a Third-Generation EGFR Inhibitor
journal contribution
posted on 2020-01-28, 16:04 authored by Li Xu, Hailong Wang, Zihan Chu, Lawrence Cai, Haifeng Shi, Chunyin Zhu, Donghui Pan, Jia Pan, Xiang Fei, Yabin LeiLung
cancer is a complicated long-term disease, which is extremely
difficult to cure. A traditional single drug delivery system cannot
achieve desired long-term controlled release of therapeutic compounds.
Our previous studies have found that temperature-responsive micelles
demonstrated high loading efficiency and a long-term controlled release
rate, which allows them to be an efficient drug delivery system. We
utilized temperature-responsive micelles and hyaluronic acid biopolymers
to create a sandwich-like membrane based on hydrogen bonding by layer-by-layer
(LBL) self-assembly technology. The multilayer films efficiently absorbed
osimertinibthe third-generation inhibitor for nonsmall cell
lung cancer (NSCLC) treatment. The release profile of osimertinib
from the films is controlled by environmental stimuli. Block copolymer
micelles with a poly(N-isopropylacrylamide) (PNIPAM)
core were deposited into the multilayer films to introduce temperature
sensitivity to the composite thin films. By the above approach, we
built a drug carrier for the delivery of an anticancer drug, which
potentially demonstrates good loading capacity, high morphology stability,
and a controllable drug release mode. We investigated the films’
responsive behavior to temperature and ionic strength and loading
capacity of the composite membrane and explored the influence of each
component on the response of the drug release profile to environmental
triggers. The films retained their morphology integrity after several
temperature-triggered swelling/deswelling cycles based on atomic force
microscopy and ellipsometry measurements. The mechanism of the intermolecular
interaction and molecular motions in the system was studied to elucidate
the relationship between structure and delivering efficiency of the
system. Development of the LBL films can provide ideas for the modification
of traditional drug delivery materials. More importantly, nanoparticle
layer-by-layer self-assembly and micro/nanoscale structure manipulation
for controlled release of therapeutic compounds are also beneficial
to future design and development of innovative functional materials.
History
Usage metrics
Categories
Keywords
LBLThird-Generation EGFR Inhibitor Lung cancernanoparticle layer-by-layer self-assemblytemperature-responsive micellesTemperature-Responsive Multilayer Filmsdrug release modeloading capacitynonsmall cell lung cancerPNIPAMNSCLCdrug delivery materialsdrug delivery systemfilmblock copolymer micellesdrug release profile
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC