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Tandem Cyclization–Michael Reaction by Combination of Metal- and Organocatalysis

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journal contribution
posted on 02.09.2011, 00:00 by José Alemán, Virginia del Solar, Cecilia Martín-Santos, Leticia Cubo, Carmen Navarro Ranninger
The use of a catalytic amount of platinum complexes (1 mol %) was found to be compatible with different organocatalysts (DABCO or the Jørgensen–Hayashi catalyst) that were used in the functionalization of various activated methylenes. By this method, a series of lactones with C-3 quaternary centers and substitution at C-5 were prepared.

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