American Chemical Society
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Synthesis of the C1–C21 Domain of Azaspiracids‑1 and −3

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journal contribution
posted on 2013-05-17, 00:00 authored by Zhigao Zhang, Yue Ding, Jianyan Xu, Yong Chen, Craig J. Forsyth
An efficient synthesis of the C1–C21 fragment of azaspiracids-1 and −3 is described. This features a Nozaki–Hiyama–Kishi reaction to couple the AB and CD ring precursors and formation of the THF-fused ABCD trioxadispiroketal system under thermodynamic conditions.