Synthesis of the C1–C21 Domain of Azaspiracids‑1 and −3

Zhang, Zhigao; Ding, Yue; Xu, Jianyan; Chen, Yong; Forsyth, Craig J.

doi:10.1021/ol400487e.s001

ol400487e_si_001.pdf (1.94 MB)

Synthesis of the C1–C21 Domain of Azaspiracids‑1 and −3

journal contribution

posted on 2013-05-17, 00:00 authored by Zhigao Zhang, Yue Ding, Jianyan Xu, Yong Chen, Craig J. Forsyth

An efficient synthesis of the C1–C21 fragment of azaspiracids-1 and −3 is described. This features a Nozaki–Hiyama–Kishi reaction to couple the AB and CD ring precursors and formation of the THF-fused ABCD trioxadispiroketal system under thermodynamic conditions.