ol400487e_si_001.pdf (1.94 MB)

Synthesis of the C1–C21 Domain of Azaspiracids‑1 and −3

Download (1.94 MB)
journal contribution
posted on 17.05.2013, 00:00 by Zhigao Zhang, Yue Ding, Jianyan Xu, Yong Chen, Craig J. Forsyth
An efficient synthesis of the C1–C21 fragment of azaspiracids-1 and −3 is described. This features a Nozaki–Hiyama–Kishi reaction to couple the AB and CD ring precursors and formation of the THF-fused ABCD trioxadispiroketal system under thermodynamic conditions.

History

Exports