American Chemical Society
jo0c00048_si_001.pdf (5.72 MB)

Synthesis of Trifluoromethyl- and Ester Group-Substituted α‑Carbolines via Iron-Catalyzed Tandem Cyclization Reaction

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journal contribution
posted on 2020-03-04, 21:46 authored by Yumin Xu, Xiaoqian Chen, Yiqin Gao, Zicong Yan, Changfeng Wan, Jin-Biao Liu, Zhiyong Wang
An efficient approach to prepare trifluoromethyl-α-carbolines and ester group-substituted α-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)­acetonitriles and trifluoromethyl 1,3-diones or β,γ-unsaturated α-ketoesters was reported. The transformation proceeded smoothly in the presence of catalytic environmental-benign iron salts, which are used to prepare the desired products in moderate to good yields.