American Chemical Society
jo0c02326_si_001.pdf (8.89 MB)

Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water

Download (8.89 MB)
journal contribution
posted on 2020-12-23, 21:35 authored by Lei Zhao, Hongyi Yang, Ruikun Li, Ye Tao, Xiao-Feng Guo, Edward A. Anderson, Andrew Whiting, Na Wu
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.