posted on 2020-12-23, 21:35authored byLei Zhao, Hongyi Yang, Ruikun Li, Ye Tao, Xiao-Feng Guo, Edward A. Anderson, Andrew Whiting, Na Wu
Ynamides,
though relatively more stable than ynamines, are still
moisture-sensitive and prone to hydration especially under acidic
and heating conditions. Here we report an environmentally benign,
robust protocol to synthesize sulfonamide-based ynamides and arylynamines
via Sonogashira coupling reactions in water, using a readily available
quaternary ammonium salt as the surfactant.