ol8b01943_si_001.pdf (9.98 MB)
Synthesis of Enantioenriched α,α-Dichloro- and α,α-Difluoro-β-Hydroxy Esters and Amides by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation
journal contribution
posted on 2018-08-09, 19:39 authored by Long-Sheng Zheng, Phannarath Phansavath, Virginie Ratovelomanana-VidalA mild and convenient approach was
developed to prepare a series
of α,α-dihalogeno β-hydroxy esters or amides by
using commercially available Noyori’s complex [RuCl(p-cymene)(R,R)-TsDPEN]
as a catalyst (S/C = 100−200) in the asymmetric transfer hydrogenation
of the corresponding ketones. Moderate to high yields (up to 99%)
and excellent enantioselectivities (up to >99% ee) were achieved
for
a series of variously substituted dichloro and difluoro β-hydroxy
esters and amides.