American Chemical Society
ol7b02271_si_001.pdf (14.3 MB)

Synthesis of Chondroitin Sulfate A Bearing Syndecan‑1 Glycopeptide

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journal contribution
posted on 2017-08-29, 11:34 authored by Sherif Ramadan, Weizhun Yang, Zeren Zhang, Xuefei Huang
Syndecan-1 chondroitin sulfate glycopeptide was synthesized for the first time using the cassette approach. The sequence of glycosylation to form the octasaccharide serine cassette was critical. The glycopeptide was successfully assembled via a 2+ (3 + 3) glycosylation strategy followed by peptide chain elongation.