posted on 2016-07-15, 00:00authored byB. Chandrasekhar, Sewon Ahn, Jae-Sang Ryu
New
catalytic methods for the synthesis of 4-isoxazolines have
been developed via catalytic intramolecular cyclizations of propargylic N-hydroxylamines. The reactions proceed rapidly in less
than 1 h at room temperature in the presence of 5 mol % (PPh3)AuCl/5 mol % AgOTf or 5 mol % (PPh3)AuNTf2. This process features an efficient route to 4-isoxazolines
with high yields, short reaction times, and mild reaction conditions.