posted on 2018-12-13, 00:00authored byLe Van Huy, Chiaki Tanaka, Takashi Imai, Sho Yamasaki, Tomofumi Miyamoto
Fifteen
glycosyl-oxystearates were synthesized by Crich’s
4,6-benzylidene and Köening–Knorr strategies. Assessment
of structure–activity relationships using macrophage-inducible
C-type lectin (Mincle) receptor cells expressing nuclear factor of
activated T cells (NFAT)-green fluorescent protein (GFP) revealed
that four dimannopyranosyl-oxystearate analogues were Mincle agonists
and that 12-O-(2-O-α-d-mannopyranosyl)-α-d-mannopyranosyl-oxystearate was
as an activator of both mouse and human Mincle.