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Stereoselective Bioreduction of Bulky-Bulky Ketones by a Novel ADH from Ralstonia sp.

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journal contribution
posted on 01.08.2008, 00:00 by Iván Lavandera, Alexander Kern, Bianca Ferreira-Silva, Anton Glieder, Stefaan de Wildeman, Wolfgang Kroutil
Ketones with two bulky substituents, named bulky-bulky ketones, as well as less sterically demanding ketones were successfully reduced to the corresponding optically highly enriched alcohols using a novel identified recombinant short-chain alcohol dehydrogenase RasADH from Ralstonia sp. DSM 6428 overexpressed in E. coli.