am8b11655_si_001.pdf (499.93 kB)
Self-Reporting Colorimetric Analysis of Drug Release by Molecular Imprinted Structural Color Contact Lens
journal contribution
posted on 2018-09-13, 00:00 authored by Jingzhe Deng, Shan Chen, Jialun Chen, Hailong Ding, Dawei Deng, Zhuoying XieAs
a prospective ophthalmic drug delivery device, contact lenses
attract a lot of attention because of the improved drug residence
time and bioavailability. Herein, we proposed and fabricated a molecular
imprinted structural color contact lens for sustained timolol release
which could self-report the release process by color change. The specific
recognition of target timolol by molecular imprinted sites can not
only increase the loading amount and the residence time of the drug
but also endow the structure color of lens remarkable blue shift with
the accumulative release of timolol. The fascinating contact lens
can be further used for controlling release of a large number of ophthalmic
drugs and has high potential to be a new generation of functional
contact lenses.