posted on 2021-11-01, 17:03authored byPankaj
P. Jadhav, Nilesh M. Kahar, Sudam G. Dawande
We
disclosed the first efficient method for highly chemo- and regioselective
C6 alkenylation of indole-7-carboxamides using inexpensive Ru(II)
catalyst through chelation assisted C–H bond activation. Electronically
diverse indole-7-carboxamides and alkenes react efficiently to produce
a wide range of C6 alkenyl indole derivatives. Further the C6 alkenyl
indole-7-carboxamides modified to their derivatives through simple
chemical transformations. The observed regioselectivity and kinetics
has been evidenced by deuterium incorporation and intermolecular competitive
studies. In addition, for mechanistic insights, the intermediates
were analyzed by HRMS.