Pharmacological and Electrophysiological Characterization
of Novel NMDA Receptor Antagonists

Leiva, Rosana; Phillips, Matthew B.; Turcu, Andreea L.; Gratacòs-Batlle, Esther; León-García, Lara; Sureda, Francesc X.; Soto, David; Johnson, Jon W.; Vázquez, Santiago

doi:10.1021/acschemneuro.8b00154.s001

cn8b00154_si_001.pdf (316.94 kB)

Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists

journal contribution

posted on 2018-05-16, 00:00 authored by Rosana Leiva, Matthew B. Phillips, Andreea L. Turcu, Esther Gratacòs-Batlle, Lara León-García, Francesc X. Sureda, David Soto, Jon W. Johnson, Santiago Vázquez

This work reports the synthesis and pharmacological and electrophysiological evaluation of new N-methyl-d-aspartic acid receptor (NMDAR) channel blocking antagonists featuring polycyclic scaffolds. Changes in the chemical structure modulate the potency and voltage dependence of inhibition. Two of the new antagonists display properties comparable to those of memantine, a clinically approved NMDAR antagonist.