posted on 2016-03-25, 15:36authored byJin Zhao, Zongyang Li, Shuaihu Yan, Shiyang Xu, Ming-An Wang, Bin Fu, Zhenhua Zhang
A facile
and efficient Pd/C-catalyzed carbonylation of both aliphatic
and aromatic azides in the presence of amines is reported. Serving
as the widely existed fragments in an array of biological pharmaceuticals,
functionalized unsymmetrical ureas were straightforwardly synthesized
by using readily available and cheap azides with amines under CO atmosphere,
with the extrusion of N2 as the only byproduct. It was
found that not only aryl azides but also benzyl and alkyl azides were
suited for this methodology. Another feature of this procedure was
the employment of a highly efficient palladium charcoal catalytic
system.