jo5b02777_si_001.pdf (2.4 MB)
Palladium-Catalyzed Synthesis of α‑Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction
journal contribution
posted on 2016-01-27, 00:00 authored by Zhen-Bang Chen, Ying Zhang, Qing Yuan, Fang-Ling Zhang, Yong-Ming Zhu, Jing-Kang ShenAn
efficient one-pot synthesis of α-iminonitriles from readily
available aryl halides via palladium-catalyzed double isocyanide insertion
and elimination has been developed, without using various hypertoxic
cyanides and excess oxidants. Furthermore, the utility of this reaction
was demonstrated by the rapid total synthesis of quinoxaline and the
reaction of functional groups exchanged with aryl halides.