jo400503f_si_001.pdf (16.6 MB)
Palladium-Catalyzed Cascade Reactions of 1‑(3-Arylprop-2-ynyloxy)-2-bromo Benzene Derivatives with Organoboron Compounds
journal contribution
posted on 2013-05-03, 00:00 authored by Antonio Arcadi, Federico Blesi, Sandro Cacchi, Giancarlo Fabrizi, Antonella Goggiamani, Fabio MarinelliApplications
of the cascade cyclocarbopalladation reaction followed by Suzuki–Miyaura
coupling reactions of the readily available aryl-substituted propargylic
aryl ethers with arylboronic acid and potassium trans-β-styryltrifluoroborate accomplish a new versatile entry in
the synthesis of benzofuran derivatives. Notably, a new approach to
the challenging synthesis of C3 functionalized 2-unsubstituted benzofurans
has been developed by a cyclocarbopalladation/cross-coupling/aromatization
process.