ja0c07273_si_001.pdf (1.07 MB)
Oxidase-like MOF-818 Nanozyme with High Specificity for Catalysis of Catechol Oxidation
journal contribution
posted on 2020-08-27, 09:29 authored by Minghua Li, Jinxing Chen, Weiwei Wu, Youxing Fang, Shaojun DongDespite
the extensive studies of the nanozymes showing their superior
properties compared to natural enzymes and traditional artificial
enzymes, the development of highly specific nanozymes is still a challenge.
The catechol oxidase specifically catalyzing the oxidations of o-diphenol to the corresponding o-quinone
is important to the biosynthesis of melanin and other polyphenolic
natural products. In this study, we first propose that MOF-818, containing
trinuclear copper centers mimicking the active sites of natural catechol
oxidase, shows efficient catechol oxidase activity with good specificity
and no peroxidase-like characteristics. MOF-818 has good specificity
and high catalytic activity as a novel catechol oxidase nanozyme.