jo8b00089_si_001.pdf (6.23 MB)
Oxidant-Free C(sp2)–H Functionalization/C–O Bond Formation: A Kolbe Oxidative Cyclization Process
journal contribution
posted on 2018-02-23, 00:00 authored by Lei Zhang, Zhenxing Zhang, Junting Hong, Jian Yu, Jianning Zhang, Fanyang MoAn
anodic oxidation/cyclization of 2-arylbenzoic acids for the
synthesis of dibenzopyranones has been developed. The reaction proceeds
at room temperature with no oxidant or electrolyte required and exhibits
a high atom economy with H2 being the only byproduct. A
series of dibenzopyranones was obtained in good to excellent yields.
Urolithins A, B, and C are formally synthesized by adopting this method
as a key step to demonstrate its synthetic utility.