ol1c03165_si_001.pdf (5.98 MB)
Oxazaborolidinone-Mediated Asymmetric Bisvinylogous Mukaiyama Aldol Reaction
journal contributionposted on 2021-11-05, 12:07 authored by Alina Eggert, Christoph Etling, Lucas Millbrodt, Göran Schulz, Markus Kalesse
A bisvinylogous Mukaiyama aldol reaction using oxazaborolidinones as a source of chirality was developed. This methodology allows the fast assembly of conjugated dienols by expanding the vinylogy principle by two additional carbons, and can be conducted using a readily available Lewis acid at reasonable reaction times. A broad range of aromatic and aliphatic aldehydes can be used providing access to complex building blocks for polyketide synthesis.