posted on 2021-11-05, 12:07authored byAlina Eggert, Christoph Etling, Lucas Millbrodt, Göran Schulz, Markus Kalesse
A bisvinylogous Mukaiyama
aldol reaction using oxazaborolidinones
as a source of chirality was developed. This methodology allows the
fast assembly of conjugated dienols by expanding the vinylogy principle
by two additional carbons, and can be conducted using a readily available
Lewis acid at reasonable reaction times. A broad range of aromatic
and aliphatic aldehydes can be used providing access to complex building
blocks for polyketide synthesis.