ol1c03165_si_001.pdf (5.98 MB)
Oxazaborolidinone-Mediated Asymmetric Bisvinylogous Mukaiyama Aldol Reaction
journal contribution
posted on 2021-11-05, 12:07 authored by Alina Eggert, Christoph Etling, Lucas Millbrodt, Göran Schulz, Markus KalesseA bisvinylogous Mukaiyama
aldol reaction using oxazaborolidinones
as a source of chirality was developed. This methodology allows the
fast assembly of conjugated dienols by expanding the vinylogy principle
by two additional carbons, and can be conducted using a readily available
Lewis acid at reasonable reaction times. A broad range of aromatic
and aliphatic aldehydes can be used providing access to complex building
blocks for polyketide synthesis.