One-Pot Primary Aminomethylation of Aryl and Heteroaryl Halides with Sodium Phthalimidomethyltrifluoroborate

Murai, Norio; Miyano, Masayuki; Yonaga, Masahiro; Tanaka, Keigo

doi:10.1021/ol301037s.s001

ol301037s_si_001.pdf (4.83 MB)

One-Pot Primary Aminomethylation of Aryl and Heteroaryl Halides with Sodium Phthalimidomethyltrifluoroborate

journal contribution

posted on 2012-06-01, 00:00 authored by Norio Murai, Masayuki Miyano, Masahiro Yonaga, Keigo Tanaka

A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki–Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.

One-Pot Primary Aminomethylation of Aryl and Heteroaryl Halides with Sodium Phthalimidomethyltrifluoroborate

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