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Nototronesides A–C, Three Triterpene Saponins with a 6/6/9 Fused Tricyclic Tetranordammarane Carbon Skeleton from the Leaves of Panax notoginseng
journal contribution
posted on 2018-07-18, 17:54 authored by Xin-Yi Liu, Chuang-Jun Li, Fang-You Chen, Jie Ma, Shuo Wang, Yu-He Yuan, Li Li, Dong-Ming ZhangThree triterpene
saponins, nototronesides A–C (1–3), possessing an unprecedented 6/6/9 fused
tricyclic tetranordammarane core, were isolated from the leaves of Panax notoginseng. Their structures were elucidated on the
basis of spectroscopic data, and the structure of sapogenin (1a) was further confirmed by X-ray crystallography. The existence
of 1–3 adds a new dimension to the
diversity of the triterpene family. Moreover, compound 2 showed a moderate neuroprotective effect on serum deficiency-induced
cellular damage in PC12 cells.