ol9b02325_si_001.pdf (5.5 MB)
Download fileMonodentate Phosphorus Ligand-Enabled General Palladium-Catalyzed Allylic C–H Alkylation of Terminal Alkenes
journal contribution
posted on 2019-08-12, 15:09 authored by Lian-Feng Fan, Pu-Sheng Wang, Liu-Zhu GongMonodentate phosphorus
ligands have been found to enable the palladium-catalyzed
allylic C–H alkylation reaction of terminal alkenes with a
wide variety of carbon nucleophiles. Moreover, an asymmetric allylic
C–H alkylation of terminal alkenes with pyrazol-5-ones has
been established in the presence of chiral phosphoramidite ligand
and chiral phosphoric acid as co-catalyst. Mechanistic studies suggest
that a ternary Pd(0) complex, coordinated with a monodentate phosphorus
ligand, benzoquinone, and alkene, is most likely to be an active species.