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Monodentate Phosphorus Ligand-Enabled General Palladium-Catalyzed Allylic C–H Alkylation of Terminal Alkenes

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journal contribution
posted on 12.08.2019, 15:09 by Lian-Feng Fan, Pu-Sheng Wang, Liu-Zhu Gong
Monodentate phosphorus ligands have been found to enable the palladium-catalyzed allylic C–H alkylation reaction of terminal alkenes with a wide variety of carbon nucleophiles. Moreover, an asymmetric allylic C–H alkylation of terminal alkenes with pyrazol-5-ones has been established in the presence of chiral phosphoramidite ligand and chiral phosphoric acid as co-catalyst. Mechanistic studies suggest that a ternary Pd(0) complex, coordinated with a monodentate phosphorus ligand, benzoquinone, and alkene, is most likely to be an active species.