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Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles
journal contribution
posted on 2019-08-25, 12:29 authored by Jing Yu, Fan Zhao, Weiliang Gao, Xue Yang, Yanmin Ju, Lingyun Zhao, Weisheng Guo, Jun Xie, Xing-jie Liang, Xinyong Tao, Juan Li, Yao Ying, Wangchang Li, Jingwu Zheng, Liang Qiao, Subin Xiong, Xiaozhou Mou, Shenglei Che, Yanglong HouReactive
oxygen species (ROS) are crucial molecules in cancer therapy.
Unfortunately, the therapeutic efficiency of ROS is unsatisfactory
in clinic, primarily due to their rigorous production conditions.
By taking advantage of the intrinsic acidity and overproduction of
H2O2 in the tumor environment, we have reported
an ROS nanoreactor based on core–shell-structured iron carbide
(Fe5C2@Fe3O4) nanoparticles
(NPs) through the catalysis of the Fenton reaction. These NPs are
able to release ferrous ions in acidic environments to disproportionate
H2O2 into •OH radicals, which
effectively inhibits the proliferation of tumor cells both in vitro and in vivo. The high magnetization
of Fe5C2@Fe3O4 NPs is
favorable for both magnetic targeting and T2-weighted magnetic resonance imaging (MRI). Ionization of these NPs
simultaneously decreases the T2 signal
and enhances the T1 signal in MRI, and
this T2/T1 switching process provides the visualization of ferrous ions release
and ROS generation for the supervision of tumor curing. These Fe5C2@Fe3O4 NPs show great potential
in endogenous environment-excited cancer therapy with high efficiency
and tumor specificity and can be guided further by MRI.
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Fe 3 O 4environment-excited cancer therapyFe 3 O 4 Nanoparticles Reactive oxygen speciespH-Sensitive Fe 5 C 2MRIOHFe 5 C 2T 1 signalResonance Imaging Guided Cancer TherapyT 2Fe 3 O 4 NPs showproduction conditionsMagnetic Reactive Oxygen Species Nanoreactortumor specificityFenton reactiontumor cellsferrous ions releaseT 2 signaltumor environmentH 2 O 2ROS nanoreactoracidic environmentsFe 3 O 4 NPsROS generationrelease ferrous ionsresonance imagingcancer therapy
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