Iron-Catalyzed
1,2-Selective Hydroboration of N‑Heteroarenes

Zhang, Fanjun; Song, Heng; Zhuang, Xuewen; Tung, Chen-Ho; Wang, Wenguang

doi:10.1021/jacs.7b11416.s001

ja7b11416_si_001.pdf (6.07 MB)

Iron-Catalyzed 1,2-Selective Hydroboration of N‑Heteroarenes

journal contribution

posted on 2017-12-01, 00:00 authored by Fanjun Zhang, Heng Song, Xuewen Zhuang, Chen-Ho Tung, Wenguang Wang

A N₂-bridged diiron complex [Cp*(Ph₂PC₆H₄S)Fe]₂(μ-N₂) (1) has been found to catalyze the hydroboration of N-heteroarenes with pinacolborane, giving N-borylated 1,2-reduced products with high regioselectivity. The catalysis is initiated by coordination of N-heteroarenes to the iron center, while the B–H bond cleavage is the rate-determining step.