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Indium Tri(isopropoxide)-Catalyzed Selective Meerwein–Ponndorf–Verley Reduction of Aliphatic and Aromatic Aldehydes
journal contribution
posted on 2012-05-18, 00:00 authored by Jaeyoung Lee, Taekyu Ryu, Sangjune Park, Phil Ho LeeIndium tri(isopropoxide)-catalyzed Meerwein–Ponndorf–Verley
reduction of aliphatic and aromatic aldehydes in 2-propanol gave selectively
the corresponding primary alcohols in good to excellent yields at
room temperature. A wide range of functional groups including alkene,
ether, ketone, ester, nitrile, and nitro were tolerated under the
optimum reaction conditions. Chemoselective reductions were also achieved
not only between aromatic aldehyde, aromatic ketone, and epoxide but
also between aliphatic aldehyde and alkene.