Highly Efficient Synthesis of a Class of Novel Chiral-Bridged Atropisomeric Monophosphine Ligands via Simple Desymmetrization and Their Applications in Asymmetric Suzuki–Miyaura Coupling Reaction
journal contributionposted on 20.04.2012, 00:00 by Shouliang Wang, Jinjin Li, Tingting Miao, Wenhao Wu, Qing Li, Yue Zhuang, Zhongyuan Zhou, Liqin Qiu
A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki–Miyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily.