ac9b01001_si_001.pdf (1.25 MB)
Graphene Quantum Dots Wrapped Gold Nanoparticles with Integrated Enhancement Mechanisms as Sensitive and Homogeneous Substrates for Surface-Enhanced Raman Spectroscopy
journal contribution
posted on 2019-05-07, 00:00 authored by Xuran Miao, Shengping Wen, Yu Su, Jiaju Fu, Xiaojun Luo, Ping Wu, Chenxin Cai, Raz Jelinek, Li-Ping Jiang, Jun-Jie ZhuRational
engineering of highly stable and Raman-active nanostructured
substrates is still urgently in demand for achieving sensitive and
reliable surface-enhanced Raman spectroscopy (SERS) analysis in solution
phase. Herein, monodisperse N-doping graphene quantum dots wrapped
Au nanoparticles (Au-NGQD NPs) were facilely prepared, and further
their applications as substrates in SERS-based detection and cellular
imaging have been explored. The as-prepared Au-NGQD NPs exhibit superior
long-term stability and biocompatibility, as well as large enhancement
capability due to the integration of electromagnetic and chemical
enhancements. The practical applicability of the Au-NGQD NPs was verified
via the direct SERS tests of several kinds of aromatics in solution
phase. Finite-difference time-domain simulations in combination with
density functional theory calculation were also successfully used
to explain the enhancement mechanism. Furthermore, the Au-NGQD NPs
were conjugated with 4-nitrobenzenethiol (4-NBT, as reporter) and
4-mercaptophenylboronic acid (MPBA, as targeting element) to construct
the MPBA/4-NBT@Au-NGQD probes, which could specifically recognize
glycan-overexpressed cancer cells through SERS imaging on a cell surface.
The prepared Au-NGQDs show great potential as superior SERS substrates
in solution phase for on-site Raman detection.
History
Usage metrics
Categories
Keywords
MPBAglycan-overexpressed cancer cellsGraphene Quantum Dots Wrapped Gold NanoparticlesdetectionSurface-Enhanced Raman Spectroscopy Rational engineeringenhancementSERSimaging4- mercaptophenylboronic acidas-prepared Au-NGQD NPs exhibitRaman-active nanostructured substratessurface-enhanced Raman spectroscopyNBTAu-NGQD NPsIntegrated Enhancement MechanismsN-doping graphene quantum dotsFinite-difference time-domain simulationssolution phase
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC