ol8b02266_si_001.pdf (9.45 MB)
Formal [1 + 2 + 3] Annulation: Domino Access to Carbazoles and Indolocarbazole Alkaloids
journal contribution
posted on 2018-08-15, 20:50 authored by Yang Men, Zhongyan Hu, Jinhuan Dong, Xianxiu Xu, Bo TangA new
formal [1 + 2 + 3] annulation of o-alkenyl
arylisocyanides with α, β-unsaturated ketones under metal-,
base-, and acid-free conditions is disclosed. This domino reaction
provides a general protocol for the efficient and practical synthesis
of a wide range of carbazole derivatives from readily available starting
materials in a single operation. Furthermore, this methodology was
used as the key step in a protecting-group-free synthesis of indolocarbazole
alkaloids arcyriaflavin A and racemosin B.