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Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

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journal contribution
posted on 07.05.2010, 00:00 by Hideyuki Konishi, Tin Yiu Lam, Jeremiah P. Malerich, Viresh H. Rawal
Catalytic enantioselective α-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.