American Chemical Society
jo5003856_si_002.pdf (3.8 MB)

Enantio- and Diastereoselective Synthesis of Spiro-epoxyoxindoles

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journal contribution
posted on 2014-05-02, 00:00 authored by Amina Boucherif, Qing-Qing Yang, Qiang Wang, Jia-Rong Chen, Liang-Qiu Lu, Wen-Jing Xiao
An asymmetric synthesis of epoxyoxindoles from isatins has been developed by employing chiral sulfur ylides generated in situ from camphor-derived sulfonium salts. This reaction allows an efficient access to enantioenriched spiro-epoxyoxindoles under mild reaction conditions, featuring high yields and excellent enantio- and diastereoselectivities.