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Effect of Biocompatible Esters and Alcohols as Cosurfactants on Structure and Solubilization Behavior of the Zwitterionic Surfactant Tetradecyldimethylamine Oxide
journal contribution
posted on 2019-01-21, 00:00 authored by Michael Gradzielski, Klaus Horbaschek, Bruno DemeIn
this work, we compare the effect of different monoterpenoid
alcohols that differ with respect to their number of double bonds
and simple aromatic esters of variable molecular architecture as cosurfactants
on the phase behavior of the zwitterionic surfactant tetradecyldimethylamine
oxide (TDMAO) and its solubilization behavior, with respect to decane
as a model paraffin oil. The esters are shown to be potent cosurfactants
but require higher concentrations to achieve similar effects, with
respect to structural changes and solubilization enhancement. Compared
to the alcohols, they solubilize somewhat smaller amounts of decane,
do reduce the interfacial tension substantially less, and also do
not form an isotropic phase of unilamellar vesicles (L4) but directly multilamellar vesicles (Lαl). A very
interesting effect is the significance of the detailed molecular architecture
of the esters, as ethyl benzoate and benzyl acetate, both having the
same sum formula, differ significantly, with respect to their cosurfactant
properties. However, all systems allow one to incorporate relatively
large amounts of the oil. For the case of the esters, this always
leads to the formation of oil-in-water (O/W) microemulsion droplets
while the alcohols can build in relatively large amounts of oil within
their vesicular structures. These findings show that these biofriendly
cosurfactants allow to formulate structurally rather versatile systems
and efficiently enhance oil solubility for the given surfactant system.
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estersbiofriendly cosurfactantssolubilization behaviorphase behaviorzwitterionic surfactant tetradecyldimethylamine oxideL 4cosurfactant propertiesmodel paraffin oilethyl benzoatesolubilization enhancementmultilamellar vesiclesoil solubilitysum formulaZwitterionic Surfactant Tetradecyldimethylamine OxideTDMAOunilamellar vesiclesL α lmonoterpenoid alcoholsSolubilization Behaviordecanefindings showsurfactant systemBiocompatible Estersbenzyl acetate
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