jo8b01613_si_001.pdf (4.32 MB)
Dynamic Kinetic Resolution for Construction of Three Transannular Stereocenters of Dihydrobenzofuranols
journal contribution
posted on 2018-09-17, 00:00 authored by Lizhen Fang, Fangfei Zhao, Shuyu Hu, Lili Han, Xiaojing Hu, Mingyong Wang, Qianqian Sun, Huipan WuA handy
and effective method was established to obtain the cis-2,3-dihydrobenzofuranols having three stereocenters,
involving asymmetric transfer hydrogenation of benzofuranones via
dynamic kinetic resolution. The general applicability of this method
was examined with different benzofuran-3-(2H)-ones,
and stereoselectivities of 85–99% ee and up to 98/2 dr were
obtained.
