posted on 2019-05-30, 20:03authored byFang-Yu Yuan, Xiao-Ling Wang, Tian Wang, Tao Shen, Dongmei Ren, Hongxiang Lou, Xiao-Ning Wang
Three new C21 pregnane
steroids, chonemorphols A–C
(1, 3, and 4), 11 new C21 steroidal glycosides, chonemorphosides A–K (2 and 5–14), and 11 known
compounds (15–25) were obtained from
the vines and leaves of Chonemorpha megacalyx Pierre.
Their structures were established using extensive spectroscopic data.
The X-ray crystallographic data of 1 and 3 permitted definition of their absolute configurations. Notably, 1 and 2 possessed an uncommon 6/5/6/5/5-fused
steroidal ring system. Compound 7 displayed significant
cytotoxicity against several cancer cell lines with IC50 values of 2.0–3.6 μM.