np9b00803_si_003.pdf (5.59 MB)
Cytotoxic 20,22-Dihydrodigitoxigenin Glycosides and Other Constituents of Vallaris glabra Stems
journal contribution
posted on 2019-12-10, 18:39 authored by Sudarat Kruakaew, Chonticha Seeka, Jantana Yahuafai, Pongpun Siripong, Somyote SutthivaiyakitTen cardiac glycosides (1–10)
including six 20,22-dihydrodigitoxigenin and four gitoxigenin glycosides
were isolated from the stems of Vallaris glabra together
with six known triterpenoid cinnamates. Spectroscopic data of these
previously undescribed compounds are reported. All isolates were evaluated
for their growth inhibitory activities against three cancer cell lines,
and compound 2 was the most active against KB cells with
an IC50 value of 0.03 ± 0.001 μM. Also, compounds 1, 3, 5, and 6 and
the triterpenoid cinnamates 11–13 showed inhibitory activity (IC50 < 10 μM) for
one or more of the cell lines used.