American Chemical Society
ol052058u_si_001.pdf (2.28 MB)

Cyclohexenones as Michael Acceptors in the Staunton−Weinreb Annulation: A Simple Stannane Modification for the Synthesis of Polycyclic Systems

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journal contribution
posted on 2005-11-10, 00:00 authored by Bryan Hill, Russell Rodrigo
o-Toluate anions generated via transmetalation from the corresponding tributyl stannane underwent a Michael addition−Dieckmann condensation sequence with various cyclohexenones. This protocol provides an efficient entry into complex polycyclic systems without the use of β-alkoxy enones hitherto required for the reaction.