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Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135

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journal contribution
posted on 23.05.2014, 00:00 authored by Feng-Yu Du, Peng Zhang, Xiao-Ming Li, Chun-Shun Li, Chuan-Ming Cui, Bin-Gui Wang
Three new cyclohexadepsipeptides of the isaridin class including isaridin G (1), desmethylisaridin G (2), and desmethylisaridin C1 (3), along with three related known metabolites (46), were isolated and identified from the marine bryozoan-derived fungus Beauveria felina EN-135. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, and the structures and absolute configurations of compounds 13 were confirmed by single-crystal X-ray diffraction analysis. The crystal structures showed the presence of β-turns for the Tyr3/N-Me-Val4 and Phe3/N-Me-Val4 amide bonds in compounds 2 and 3, respectively, in the cis conformations, which were opposite other reported isaridins. The conformations of the HMPA1-Pro2 amide bond in compound 2 are different in the solution and in the crystal structures, which showed trans and cis geometries, respectively, while compounds 1 and 3 do not exhibit this phenomenon. Each of the isolated compounds was evaluated for antimicrobial activity and brine shrimp lethality. Compound 3 exhibited antibacterial activity against E. coli with an MIC value of 8 μg/mL.