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Copper-Catalyzed Electrophilic Amination of Heteroarenes via C–H Alumination

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journal contribution
posted on 16.10.2015, 00:00 by Hongju Yoon, Yunmi Lee
A highly efficient Cu-catalyzed electrophilic amination reaction of readily available heteroarenes with O-benzoyl hydroxylamines via a one-pot C–H alumination is reported. The reactions were catalyzed using 1 mol % of CuCl to afford various heteroaryl amines in good to excellent yields. The direct C–H lithiation/transalumination of heteroarenes and catalytic amination sequence can be performed in a single vessel on gram scales.

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