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Copper-Catalyzed Cross Dehydrogenative Coupling Reactions of Tertiary Amines with Ketones or Indoles

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journal contribution
posted on 19.11.2010, 00:00 authored by Fei Yang, Jian Li, Jin Xie, Zhi-Zhen Huang
A novel cross dehydrogenative coupling (CDC) reaction of N,N-dimethylanilines with methyl ketones by cooperative copper and aminocatalysis has been developed, which leads to the formation of β-arylamino ketones in 42−73% yields. Moreover, the copper-catalyzed alkylation of free (NH) indoles with N,N-dimethylanilines via CDC reaction is also presented, affording alkylated indoles in 52−78% yields.

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