American Chemical Society
ol2c00151_si_001.pdf (9 MB)

Catalytic Transformations of 2‑Pyridones by Rhodium-Mediated Carbene Transfer

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journal contribution
posted on 2022-02-22, 14:36 authored by Jiahui Su, Qiongya Li, Ying Shao, Jiangtao Sun
An enantioselective cyclopropanation reaction of N-substituted 2-pyridones with diazo compounds has been realized by using a chiral rhodium complex as the catalyst, and the corresponding chiral cyclopropanes could be formed in good yields with high enantioselectivities. Moreover, using acceptor–acceptor dimethyl 2-diazomalonate as the carbene precursor, a novel 1,4-rearrangement of a Boc group from N to C has also been discovered under rhodium catalysis.