posted on 2022-02-22, 14:36authored byJiahui Su, Qiongya Li, Ying Shao, Jiangtao Sun
An
enantioselective cyclopropanation reaction of N-substituted
2-pyridones with diazo compounds has been realized by
using a chiral rhodium complex as the catalyst, and the corresponding
chiral cyclopropanes could be formed in good yields with high enantioselectivities.
Moreover, using acceptor–acceptor dimethyl 2-diazomalonate
as the carbene precursor, a novel 1,4-rearrangement of a Boc group
from N to C has also been discovered under rhodium catalysis.