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Biodirected Synthesis and Nanostructural Characterization of Anisotropic Gold Nanoparticles
journal contribution
posted on 2015-03-24, 00:00 authored by Germán Plascencia-Villa, Daniel Torrente, Marcelo Marucho, Miguel José-YacamánGold nanoparticles with anisotropic
structures have tunable absorption
properties and diverse bioapplications as image contrast agents, plasmonics,
and therapeutic–diagnostic materials. Amino acids with electrostatically
charged side chains possess inner affinity for metal ions. Lysine
(Lys) efficiently controlled the growing into star-shape nanoparticles
with controlled narrow sizes (30–100 nm) and produced in high
yields (85–95%). Anisotropic nanostructures showed tunable
absorbance from UV to NIR range, with extraordinary colloidal stability
(−26 to −42 mV) and surface-enhanced Raman scattering
properties. Advanced electron microscopy characterization through
ultra-high-resolution SEM, STEM, and HR-TEM confirmed the size, nanostructure,
crystalline structure, and chemical composition. Molecular dynamics
simulations revealed that Lys interacted preferentially with Au(I)
through the −COOH group instead of their positive side chains
with a binding free energy (BFE) of 3.4 kcal mol–1. These highly monodisperse and colloidal stable anisotropic particles
prepared with biocompatible compounds may be employed in biomedical
applications.
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BiodirectedcompoundstabilityplasmonicRamanaffinitybioapplicationSynthesiMolecular dynamics simulationsmaterialmolLysyieldNIR3.4acidNanostructuralabsorbanceelectrostaticallyCOOHUVimage contrast agentskcalAminoLysineinteractedanisotropicSEMAnisotropic Gold NanoparticlesGold nanoparticlesmVCharacterizationBFEbindingnmtunable absorption propertieschemicalapplicationside chainsbiocompatibleAdvanced electron microscopy characterizationnanostructure
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