Automated Image Analysis for Single-Atom Detection in Catalytic Materials by Transmission Electron Microscopy
journal contributionposted on 25.03.2022, 14:40 authored by Sharon Mitchell, Ferran Parés, Dario Faust Akl, Sean M. Collins, Demie M. Kepaptsoglou, Quentin M. Ramasse, Dario Garcia-Gasulla, Javier Pérez-Ramírez, Núria López
Single-atom catalytic sites may have existed in all supported transition metal catalysts since their first application. Yet, interest in the design of single-atom heterogeneous catalysts (SACs) only really grew when advances in transmission electron microscopy (TEM) permitted direct confirmation of metal site isolation. While atomic-resolution imaging remains a central characterization tool, poor statistical significance, reproducibility, and interoperability limit its scope for deriving robust characteristics about these frontier catalytic materials. Here, we introduce a customized deep-learning method for automated atom detection in image analysis, a rate-limiting step toward high-throughput TEM. Platinum atoms stabilized on a functionalized carbon support with a challenging irregular three-dimensional morphology serve as a practically relevant test system with promising scope in thermo- and electrochemical applications. The model detects over 20,000 atomic positions for the statistical analysis of important properties for establishing structure–performance relations over nanostructured catalysts, like the surface density, proximity, clustering extent, and dispersion uniformity of supported metal species. Good performance obtained on direct application of the model to an iron SAC based on carbon nitride demonstrates its generalizability for single-atom detection on carbon-related materials. The approach establishes a route to integrate artificial intelligence into routine TEM workflows. It accelerates image processing times by orders of magnitude and reduces human bias by providing an uncertainty analysis that is not readily quantifiable in manual atom identification, improving standardization and scalability.
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transmission electron microscopysupported metal speciesresolution imaging remainsreduces human biasplatinum atoms stabilizedmetal site isolationiron sac basedintegrate artificial intelligencegood performance obtaineddimensional morphology servederiving robust characteristicschallenging irregular threecentral characterization toolmanual atom identificationpoor statistical significancepermitted direct confirmationfunctionalized carbon supportcarbon nitride demonstratesautomated atom detectionatom heterogeneous catalystsroutine tem workflows000 atomic positionsfrontier catalytic materialsautomated image analysisatom detectioncatalytic materialsstatistical analysisimage analysisnanostructured catalystsdirect applicationrelated materialsuncertainty analysisthroughput temsurface densityreally grewreadily quantifiablelearning methodinteroperability limitimproving standardizationimportant propertiesfirst applicationelectrochemical applicationsdispersion uniformitycustomized deepclustering extentapproach establishes