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Antiviral Properties of Polymeric Aziridine- and Biguanide-Modified Core–Shell Magnetic Nanoparticles

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journal contribution
posted on 06.03.2012, 00:00 by Lev Bromberg, Daniel J. Bromberg, T. Alan Hatton, Isabel Bandín, Angel Concheiro, Carmen Alvarez-Lorenzo
Polycationic superparamagnetic nanoparticles (∼150–250 nm) were evaluated as virucidal agents. The particles possess a core–shell structure, with cores consisting of magnetite clusters and shells of functional silica covalently bound to poly­(hexamethylene biguanide) (PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine moieties. Aziridine was conjugated to the PEI shell through cationic ring-opening polymerization. The nanometric core–shell particles functionalized with biguanide or aziridine moieties are able to bind and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic septicaemia virus (VHSV). The virus–particle complexes can be efficiently removed from the aqueous milieu by simple magnetocollection.