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Analysis and Isolation of Potential Artemisinin Precursors from Waste Streams of Artemisia Annua Extraction
journal contribution
posted on 2018-07-12, 17:21 authored by Rodger W. Stringham, Gary L. Moore, David S. Teager, Tai-Yuen YueHigh-performance liquid chromatography,
liquid chromatography–mass
spectrometry, and gas chromatography–mass spectrometry methods
were developed to analyze the process waste streams of Artemisia Annua extraction. Results from these methods
suggested that the final waste from the extraction process could serve
as a source of dihydroartemisinic acid (DHAA) that could be converted
to additional artemisinin. Two additional impurities were isolated
and identified in the waste material as well as in A. annua leaf samples. That these impurities also
appear as side-products in chemical transformations of DHAA to artemisinin
supports the conclusion that the in vivo transformation proceeds as
nonspecific oxidations. These impurities do not appear in isolated
artemisinin. A simple, high-yielding procedure for recovery of DHAA
from the primary waste stream was developed.
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annua leaf sampleschemical transformationsvivo transformation proceedsimpuritywaste materialwaste streammethoddihydroartemisinic acidchromatographyWaste StreamsPotential Artemisinin PrecursorsDHAAextraction processartemisininArtemisia Annua Extraction High-performanceArtemisia Annua extractionspectrometryprocess waste streams
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