Alkynyl Borrowing: Silver-Catalyzed
Amination of Secondary
Propargylic Alcohols via C(sp3)–C(sp) Bond Cleavage

Zhuang, Xin; Zhu, Min; Hong, Chuan-Ming; Luo, Zhen; Li, Wan-Fang; Li, Qing-Hua; Luo, Qun-Li; Liu, Tang-Lin

doi:10.1021/acs.joc.2c00297.s001

jo2c00297_si_001.pdf (5.83 MB)

Alkynyl Borrowing: Silver-Catalyzed Amination of Secondary Propargylic Alcohols via C(sp³)–C(sp) Bond Cleavage

journal contribution

posted on 2022-04-06, 21:30 authored by Xin Zhuang, Min Zhu, Chuan-Ming Hong, Zhen Luo, Wan-Fang Li, Qing-Hua Li, Qun-Li Luo, Tang-Lin Liu

The silver-catalyzed alkynyl borrowing amination of secondary propargyl alcohols via C(sp³)–C(sp) bond cleavage has been developed. This new strategy was based on the β-alkynyl elimination of propargyl alcohols and alkynyl as the borrowing subject. This alkynyl borrowing amination featured high atom economy, wide functional group tolerance, and high efficiency.