ol8b00497_si_001.pdf (2.32 MB)
Access to Quaternary Stereogenic Centers via Rhodium(III)-Catalyzed Annulations between 2‑Phenylindoles and Ketenes
journal contribution
posted on 2018-03-23, 18:34 authored by Xifa Yang, Yunyun Li, Lingheng Kong, Xingwei LiRh(III)-catalyzed
C–H activation of arenes and mild oxidative
[4 + 2] annulative coupling with ketenes have been realized. The uniquely
high reactivity of the C(3) of 2-phenylindoles was successfully utilized
to facilitate the reductive elimination process, leading to efficient
synthesis of cyclic products with a quaternary carbon stereocenter.