A Catalyst-Free Synthesis of Phosphinic Amides Using O‑Benzoylhydroxylamines

A practical approach for the synthesis of phosphinic amides via the coupling of secondary phosphine oxides (SPOs) with O-benzoyl­hydroxyl­amines has been reported. Simply heating the mixture of SPOs and O-benzoylhydroxylamines in the presence of K₂CO₃ gave the phosphinic amides in moderate to excellent yields under an open air system. This method provides a practical and catalyst-free method for the synthesis of various synthetically valuable phosphinic amides.