American Chemical Society
ol5b03056_si_001.pdf (4.72 MB)

A Catalyst-Free Synthesis of Phosphinic Amides Using O‑Benzoylhydroxylamines

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journal contribution
posted on 2015-12-04, 00:00 authored by Rui Zhu, Chongqing Pan, Zhenhua Gu
A practical approach for the synthesis of phosphinic amides via the coupling of secondary phosphine oxides (SPOs) with O-benzoyl­hydroxyl­amines has been reported. Simply heating the mixture of SPOs and O-benzoylhydroxylamines in the presence of K2CO3 gave the phosphinic amides in moderate to excellent yields under an open air system. This method provides a practical and catalyst-free method for the synthesis of various synthetically valuable phosphinic amides.