ol9b00187_si_001.pdf (21.47 MB)
1,4-Palladium Shift/C(sp3)–H Activation Strategy for the Remote Construction of Five-Membered Rings
journal contribution
posted on 2019-02-08, 19:50 authored by Ronan Rocaboy, Olivier Baudoin1,n-Metal shift is an elegant alternative approach
enabling the functionalization of remote C–H bonds from simple
precursors. In this work, we report a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C(sp3)–H activation and leading to (fused) five-membered
rings. This method allowed access to a broad range of valuable arylidene
γ-lactams and indanones and was applied to the formal synthesis
of (−)-pyrrolam.