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Synthesis of Proposed Aglycone of Mandelalide A

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journal contribution
posted on 16.05.2014 by Karla Mahender Reddy, Vanipenta Yamini, Kiran K. Singarapu, Subhash Ghosh
A highly convergent synthesis of the proposed mandelalide A aglycone is reported. The cornerstones of the synthetic strategy include the following: E-selective intramolecular Heck cyclization, Masamune–Roush olefination, Stork–Zhao–Wittig olefination, modified Prins cyclization; Sharpless asymmetric dihydroxylation followed by Williamson-type etherification, Julia–Kocienski olefination, Brown crotylation, and Brown allylation reactions.