Synthesis of Proposed Aglycone of Mandelalide A
journal contributionposted on 16.05.2014 by Karla Mahender Reddy, Vanipenta Yamini, Kiran K. Singarapu, Subhash Ghosh
Any type of content formally published in an academic journal, usually following a peer-review process.
A highly convergent synthesis of the proposed mandelalide A aglycone is reported. The cornerstones of the synthetic strategy include the following: E-selective intramolecular Heck cyclization, Masamune–Roush olefination, Stork–Zhao–Wittig olefination, modified Prins cyclization; Sharpless asymmetric dihydroxylation followed by Williamson-type etherification, Julia–Kocienski olefination, Brown crotylation, and Brown allylation reactions.